In today’s globalized world, labor mobility is at the core of the political debate and a centerpiece for economic policy. The design of efficient migration policies requires a good understanding of a very fundamental issue: understanding the role of internal migration and immigration in shaping the career paths and human capital accumulation of workers. The project DYMOLAMO aims at providing a coherent analysis that allows us to understand the interactions between labor mobility and human capital accumulation, and their implications for economic policy design. DYMOLAMO focuses on three main issues: labor mobility, labor market effects of immigration, and the interaction between the two. In particular, it focuses on the following questions: (a) What are the role of temporary and permanent contracts in shaping career paths and geographic mobility of workers? (b) Does the forgone human capital accumulation during a recession produce a lost generation? Is this alleviated by geographical mobility? (c) What is the role of geographical and occupational mobility in spreading or containing the effects of technological progress on wage inequality? (d) To what extent selective immigration policies maximize native workers’ prospects and wellbeing? (e) How can we increase the degree of assimilation of immigrants? To address them, DYMOLAMO develops dynamic equilibrium models that explicitly characterize human capital accumulation decisions of workers and how these decisions interact with migration, and develops novel estimation methods for them. The estimated models are used to evaluate and design key economic policies for the labor market.